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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTNNB1
All Species:
24.55
Human Site:
S23
Identified Species:
41.54
UniProt:
P35222
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P35222
NP_001091679.1
781
85497
S23
P
D
R
K
A
A
V
S
H
W
Q
Q
Q
S
Y
Chimpanzee
Pan troglodytes
XP_001137676
774
84747
S22
V
S
H
W
Q
Q
Q
S
Y
L
D
S
G
I
H
Rhesus Macaque
Macaca mulatta
XP_001115474
511
55731
Dog
Lupus familis
XP_850439
744
81740
T19
K
V
T
E
W
Q
Q
T
Y
T
Y
D
S
G
I
Cat
Felis silvestris
Mouse
Mus musculus
Q02248
781
85452
S23
P
D
R
K
A
A
V
S
H
W
Q
Q
Q
S
Y
Rat
Rattus norvegicus
Q9WU82
781
85436
S23
P
D
R
K
A
A
V
S
H
W
Q
Q
Q
S
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516985
781
85506
S23
P
D
R
K
A
A
V
S
H
W
Q
Q
Q
S
Y
Chicken
Gallus gallus
NP_990412
781
85420
S23
P
D
R
K
A
A
V
S
H
W
Q
Q
Q
S
Y
Frog
Xenopus laevis
P26233
781
85431
S23
P
D
R
K
A
A
V
S
H
W
Q
Q
Q
S
Y
Zebra Danio
Brachydanio rerio
NP_571134
780
85502
V22
D
P
D
R
K
A
A
V
S
H
W
Q
Q
Q
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18824
843
91134
Q31
P
M
V
S
A
K
E
Q
T
L
M
W
Q
Q
N
Honey Bee
Apis mellifera
XP_391947
811
88602
Q32
P
M
G
S
A
K
E
Q
T
L
M
W
Q
Q
N
Nematode Worm
Caenorhab. elegans
O44326
678
74493
E18
I
F
T
D
H
E
V
E
T
R
T
S
R
I
R
Sea Urchin
Strong. purpuratus
NP_001027543
825
89711
G44
T
M
E
W
Q
H
H
G
Y
G
M
D
S
G
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
65.4
66.4
N.A.
99.8
99.7
N.A.
99.7
99.3
97.4
97.1
N.A.
65.7
67.6
28.5
67.2
Protein Similarity:
100
99
65.4
77.4
N.A.
99.8
99.7
N.A.
99.8
99.6
99
98.9
N.A.
77.2
80.1
46.4
77.7
P-Site Identity:
100
6.6
0
0
N.A.
100
100
N.A.
100
100
100
20
N.A.
20
20
6.6
0
P-Site Similarity:
100
20
0
20
N.A.
100
100
N.A.
100
100
100
26.6
N.A.
20
20
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
58
50
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
43
8
8
0
0
0
0
0
0
8
15
0
0
0
% D
% Glu:
0
0
8
8
0
8
15
8
0
0
0
0
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
8
0
0
0
0
8
0
8
0
0
8
15
0
% G
% His:
0
0
8
0
8
8
8
0
43
8
0
0
0
0
8
% H
% Ile:
8
0
0
0
0
0
0
0
0
0
0
0
0
15
8
% I
% Lys:
8
0
0
43
8
15
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
22
0
0
0
0
0
% L
% Met:
0
22
0
0
0
0
0
0
0
0
22
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
15
% N
% Pro:
58
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
15
15
15
15
0
0
43
50
65
22
0
% Q
% Arg:
0
0
43
8
0
0
0
0
0
8
0
0
8
0
8
% R
% Ser:
0
8
0
15
0
0
0
50
8
0
0
15
15
43
8
% S
% Thr:
8
0
15
0
0
0
0
8
22
8
8
0
0
0
0
% T
% Val:
8
8
8
0
0
0
50
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
15
8
0
0
0
0
43
8
15
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
22
0
8
0
0
0
43
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _